USC-Oregon, Missouri-Oklahoma and betting lines for every top-25 team

ByESPN ESPN logo
Friday, November 21, 2025
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The biggest matchup of the weekend is a Big Ten clash on the West Coast, with the USC Trojans challenging the Oregon Ducks. "College GameDay" will be making its second visit of the season to Eugene, Oregon, to start a busy Saturday of college football.

Texas A&M survived a scare against South Carolinabefore bouncing back to win. The Aggies will face FCS Samford in College Station, Texas. Elsewhere in the SEC, there are only four intraconference matchups, including Kentucky at Vanderbilt, Arkansasagainst Texas, Tennessee against rival Florida, and Missourivs. Oklahoma.

Ohio Stateis still undefeated, and the Buckeyes will begin Saturday's action when they kick off against Rutgersat noon ET. Notre Dame,the highest-ranked two-loss team, will welcome ACC opponent Syracuse to South Bend, Indiana.

>Saturday, Noon, FOX

Records: Rutgers 5-5, 0-1 vs. AP teams; Ohio State 10-0, 2-0 vs. AP teams

>Opening Line: Ohio State -33.5

>Money line: Rutgers (+3500); Ohio State (-50000)

>Over/Under: Off

>FPI Projection Ohio State by 28.3 points with a 97% probability to win game outright

>Saturday, Noon, SECN+

Records: Samford 1-10 (8th in Southern); Texas A&M 10-0, 3-0 vs. AP teams

>No line posted

>FPI Projection Texas A&M by 56.1 points with a >99% probability to win game outright

>Saturday, Noon, ABC

Records: Missouri 7-3, 0-3 vs. AP teams; Oklahoma 8-2, 4-1 vs. AP teams

>Line Movement Alert: Opened Oklahoma -9.5, O/U 42.5

>Money line: Missouri (+210); Oklahoma (-250)

>Over/Under: 42.5 (O -105, U -115)

>FPI Projection Oklahoma by 3.5 points with a 64% probability to win game outright

>Saturday, Noon, ESPN

Records: Miami 8-2, 3-0 vs. AP teams; Virginia Tech 3-7, 0-3 vs. AP teams

>Money line: Miami (-1200); Oklahoma (+700)

>Over/Under: 48.5 (O -110, U -110)

>FPI Projection Miami by 16.8 points with a 90% probability to win game outright

>Saturday, 12:45 p.m., SEC Network

Records: Charlotte 1-9, 0-0 vs. AP teams; Georgia 9-1, 3-1 vs. AP teams

>Opening Line: Georgia -44.5, O/U 55.5

>Money line: Off

>Over/Under: 53.5 (O -110, U -110)

>FPI Projection Georgia by 50.3 points with a >99% probability to win game outright

>Saturday, 2 p.m., SECN+

Records: Eastern Illinois 3-8 (8th in OVC/Big South); Alabama 8-2, 4-1 vs. AP teams

>No line posted

>FPI Projection Alabama by 57.7 points with a >99% probability to win game outright

>Saturday, 3:30 p.m., CBS

Records: USC 8-2, 1-2 vs. AP teams; Oregon 9-1, 1-1 vs. AP teams

>Opening Line: Oregon -8.5, O/U 55.5

>Money line: USC (+300); Oregon (-400)

>Over/Under: 59.5 (O -105, U -115)

>FPI Projection Oregon by 6 points with a 72% probability to win game outright

>Saturday, 3:30 p.m., NBC, Peacock

Records: Syracuse 3-7, 0-3 vs. AP teams; Notre Dame 8-2, 2-2 vs. AP teams

>Opening Line: Notre Dame -35.5, O/U 51.5

>Money line: Off

>Over/Under: 50.5 (O -115, U -105)

>FPI Projection Notre Dame by 30.2 points with a 97% probability to win game outright

>Saturday, 3:30 p.m., ESPN

Records: Kentucky 5-5, 0-4 vs. AP teams; Vanderbilt 8-2, 3-2 vs. AP teams

>Opening Line: Vanderbilt -10.5, O/U 52.5

>Money line: Kentucky (+280); Vanderbilt (-360)

>Over/Under: 54.5 (O -120, U -110)

>FPI Projection Vanderbilt by 7.7 points with a 77% probability to win game outright

>Saturday, 3:30 p.m., ABC

Records: Arkansas 2-8, 0-4 vs. AP teams; Texas 7-3, 2-2 vs. AP teams

>Opening Line: Texas -10.5, O/U 56.5

>Money line: Arkansas (+260); Texas (-320)

>Over/Under: 58.5 (O -105, U -115)

>FPI Projection Texas by 11.3 points with a 83% probability to win game outright

>Saturday, 3:45 p.m., ESPNU

Records: Tulane 8-2, 1-1 vs. AP teams; Temple 5-5, 0-2 vs. AP teams

>Opening Line: Tulane -8.5, O/U 54.5

>Money line: Tulane (-380); Temple (+290)

>Over/Under: 54.5 (O EVEN, U -120)

>FPI Projection Tulane by 4.4 points with a 66% probability to win game outright

>Saturday, 4 p.m., ESPN2

Records: Kansas State 5-5, 0-2 vs. AP teams; Utah 8-2, 2-2 vs. AP teams

>Opening Line: Utah -17.5, O/U 52.5

>Money line: Kansas State (+550); Utah (-900)

>Over/Under: 51.5 (O -110, U -110)

>FPI Projection Utah by 15.4 points with a 89% probability to win game outright

>Saturday, 4 p.m., BTN

Records: Michigan 8-2, 0-1 vs. AP teams; Maryland 4-6, 0-1 vs. AP teams

>Opening Line: Michigan -13.5, O/U 45.5

>Money line: Michigan (-800); Maryland (+500)

>Over/Under: 46.5 (O -105, U -115)

>FPI Projection Michigan by 10.6 points with a 82% probability to win game outright

>Saturday, 4 p.m., FOX

Records: TCU 6-4, 0-1 vs. AP teams; Houston 8-2, 1-1 vs. AP teams

>Opening Line: Houston -2.5, O/U 54.5

>Money line: TCU (+EVEN); Houston (-120)

>Over/Under: 54.5 (O -105, U -105)

>FPI Projection TCU by 0.8 points with a 53% probability to win game outright

>Saturday, 7 p.m., ESPN

Records: Pittsburgh 7-3, 1-1 vs. AP teams; Georgia Tech 9-1, 1-0 vs. AP teams

>Opening Line: Georgia Tech -2.5, O/U 61.5

>Money line: Pittsburgh (+115); Georgia Tech (-135)

>Over/Under: 61.5 (O -105, U -115)

>FPI Projection Georgia Tech by 1.6 points with a 57% probability to win game outright

>Saturday, 7:30 p.m., ABC

Records: Tennessee 7-3, 0-3 vs. AP teams; Florida 3-7, 1-5 vs. AP teams

>Opening Line: Tennessee -3.5, O/U 57.5

>Money line: Tennessee (-190); Florida (+160)

>Over/Under: 57.5 (O -110, U -110)

>FPI Projection Tennessee by 3.8 points with a 65% probability to win game outright

>Saturday, 7:30 p.m., BTN

Records: Illinois 7-3, 1-2 vs. AP teams; Wisconsin 3-7, 1-5 vs. AP teams

>Opening Line: Illinois -9.5, O/U 42.5

>Money line: Illinois (-380); Wisconsin (+290)

>Over/Under: 41.5 (O -110, U -110)

>FPI Projection Illinois by 5.8 points with a 72% probability to win game outright

>Saturday, 8 p.m., FOX

Records: BYU 9-1, 1-1 vs. AP teams; Cincinnati 7-3, 1-1 vs. AP teams

>Opening Line: BYU -2.5, O/U 53.5

>Money line: BYU (-135); Cincinnati (+115)

>Over/Under: 55.5 (O -115, U -105)

>FPI Projection BYU by 4.7 points with a 68% probability to win game outright

>Saturday, 8 p.m., ESPN2

Records: Arizona State 7-3, 2-0 vs. AP teams; Colorado 3-7, 1-1 vs. AP teams

>Opening Line: Arizona State -8.5, O/U 48.5

>Money line: Arizona State (-290); Colorado (+240)

>Over/Under: 46.5 (O -115, U -105)

>FPI Projection Arizona State by 3.4 points with a 63% probability to win game outright

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