The nation's leading rusher entering the weekend, Abdullah was hurt while diving to recover a fumble at the Purdue 1 on a fourth-down fumble by quarterback Tommy Armstrong Jr.
Abdullah was fitted with a sleeve over his left knee and returned for one possession, rushing once for a 5-yard loss. He then returned to the sideline as trainers applied ice to the knee.
Nebraska backups Imani Cross and Terrell Newby have shared time in Abdullah's absence.
Nebraska Tops Purdue; Abdullah Leaves Game
No. 15 Nebraska tops Purdue, but Huskers running back Ameer Abdullah was hurt in the first quarter and did not return.
Ameer Abdullah Hurt On Play
Ameer Abdullah ran for no gain, but he was injured on the play and left the game.