The California Highway Patrol's Fort Tejon station announced the closure at Lebec Road shortly after 8 a.m. No major injuries were reported.
According to Caltrans, the collision spilled chloride in the northbound lanes.
The #1 and #2 lanes of northbound I-5 are now open. Expect delays for northbound traffic due to the two lane closure and congestion.— CHP Fort Tejon (@CHPFortTejon) April 1, 2020
Southbound has all lanes open and is flowing smoothly. pic.twitter.com/7Wyfjh610E
The cause of the crash is under investigation.
Highway 138's westbound connector to the northbound 5 was closed amid the cleanup operation, Caltrans said.
All southbound lanes were reopened on the 5 before noon, and two northbound lanes were reopened shortly before 1:30 p.m., the CHP said.