AAA forecasts 107.3 million Americans will take to planes, trains, automobiles and other modes of transportation during the year-end holiday period from Saturday, Dec. 23 through Monday, Jan. 1.
In SoCal, 8.2 million people will travel during the 10-day period, and the vast majority - 7.2 million - will go by car or trucks.
AAA and analytics company INRIX looked at historical and recent travel trends to predict the time drivers will experience the greatest amount of congestion on the roads.
In Los Angeles, the worst day to drive will be Wednesday (Dec. 20) between 3:30 p.m. and 6 p.m., when delays are projected to be 2.5 times longer than usual.
With so many drivers hitting the roads, AAA's Doug Shupe said it's important for people to check their cars before taking off.
"Really make sure that you inspect that vehicle you're taking. Make sure the tires are in good working order, your fluid levels are topped off, check for any cracking or fraying in the belts or hoses. You want to make sure that vehicle is in good working order to prevent a breakdown on the side of the highway," he said.
Shupe also had some advice on getting around the worst of the holiday traffic.
"It's best if you can leave as early in the day as possible. And if your schedule allows traveling on the holiday, you'll typically see a lot less traffic on the freeway," he said.
Shupe also emphasized the big safety concern regarding people driving after using marijuana.
"For generations we've been talking about the dangers of drinking and driving. (Using) marijuana and driving is dangerous as well. Please do not get behind the wheel after any amount of alcohol or drugs," Shupe said.
VIDEO: Police warn against driving under influence of marijuana
Law enforcement officials are preparing for the recreational use of marijuana becoming legal on Jan. 1.
"We're deploying more officers on the streets to make sure the public is safe," said CHP Officer Glen Glacer Jr.
It's a tragedy Louis Bianco lives with daily. He barely survived being hit by a drunk driver on his bicycle eight years ago.
He now has metal infused in his jaw, hip and hands.
"You can not only kill yourself but you can injure yourself. You can actually take someone out who is innocent like me. And it's not just the suffering to someone like me, it's the suffering to, say, a family member," Bianco said.
There were nearly 10,500 drunk driving deaths in 2016, according to the National Highway Traffic Safety Administration. That's a 1.7 percent increase from the year before.
Mohamed Hariri's sister, Malak was killed along with four others in a DUI crash in Burbank several years ago. The coroner reported that the driver, who was also killed, had taken both alcohol and marijuana.
"When you drive and you're high, it's not a video game. When you get hit, you actually hit someone. You can't just restart the button," Hariri said.
Police officers are preparing for the legalization of marijuana in 2018.
"We look at marijuana, prescription medication, there's so many things that could determine whether you're impaired or not. When you take it, how much you take it, we don't know until we get that person out of the car and we test them and see how they perform on a standardized field sobriety test," said LAPD Sgt. Mike Delgadillo.
Law enforcement and traffic safety officials say with companies like Lyft and Uber, it's simply not worth it to drive under the influence.