The suspects' white Nissan sedan was speeding southbound on Atlantic Avenue when it slammed into a grey Chrysler sedan trying to make a left turn near East Rosecrans Avenue.
"They see the pursuit coming southbound towards them. They come almost to a full stop. The driver of the white car loses control and is sideways when it collides with the grey car that is almost stopped. The driver and the passenger of the white car sustained fatal injuries," said CHP Sgt. T. Uemura.
The two occupants in the Chrysler sustained only minor to moderate injuries and were taken to a nearby hospital for treatment.
The identities of the two men who died in the collision have not been released by the coroner's office.
CNS contributed to this report.