His character expects a lot out from the young doctors who come to this clinic to work.
"Otis is the drill sergeant, the hard ass. That's a lot of fun to play," George said. "He doesn't suffer fools lightly and everybody's a fool until you prove yourself otherwise. The place has a big turnover of people so, if I'm going to lose you in a month, I'll get rid of you today."
Valerie Cruz plays another veteran of the South American clinic.
Where in South America? We'll never know because the show's creator, Shonda Rimes, didn't want to be bound to a specific place.
"In a way, it's become its own little world," Cruz said. "It's a Latin melting pot, so in some ways it's great. In other ways it's challenging, as far as dialect and keeping it neutral."
Expect the medical emergencies to be unlike other shows in this genre.
"With this location, you've got the beauty and so many things can kill you," George said. "Somebody's trapped underwater. Get the gear, go scuba diving and then you perform surgery."
To create South America, "Off the Map" shoots in Hawaii, far away from Hollywood.
"Where we do shoot, it's very remote," Cruz said. "On the flip side, it makes us closer. I think a lot of what you see on screen is because we are we're in it together."
"Off the Map" airs at 10 p.m. Wednesday on ABC7.