With his Sept. 24 appearance, the "30 Rock" actor surpasses Steve Martin, who has hosted the show 15 times. The network announced Friday that Radio Head will be the musical guest.
Melissa McCarthy of CBS' "Mike & Molly" and the movie "Bridesmaids" will be the host of the show's second week, her "SNL" debut. The country trio Lady Antebellum will be her musical guest.
The Associated Press contributed to this report.