Perry, who was in Indianapolis to perform at DirectTV's pre-Super Bowl party on Saturday, served as a presenter at The Associated Press NFL Awards.
The "Firework" singer flirted with co-presenter Cam Newton saying, " "You'll be the first straight man I've had a photo with in a long time, so live up to it."
The Carolina Panthers star smiled big and replied, "I am."
Newton won the 2011 offensive rookie of the year award.
Perry's husband, comedian Russell Brand, filed for divorce earlier in the year from the singer.
The Associated Press contributed to this report.