The incident occurred near the intersection of Rubidoux Boulevard and El Revino Road around 10 p.m.
Jurupa Valley police said three cars had been involved in a collision. Firefighters rescued two people trapped in the wreckage.
The five injured people were transported to a local hospital where one of the five succumbed to his injuries. Investigators believe alcohol may have been a factor in the crash. The investigation to determine the cause of the collision is ongoing.
Anyone with information was urged to call Jurupa Valley Station Traffic Team at (951) 955-2600.