California Highway Patrol officers responded to the scene at 8:38 p.m. on the 14, near Puritan Mine Road, according to the agency.
Paola Rios, a Golden Valley High School student, said the school's volleyball team was returning home from a game in Palmdale at the time of the incident.
Guys our bus got caught on fire and we're stuck on the side of the freeway THIS CRAZYYYYY pic.twitter.com/B210pnVUk1— p🌞w (@riosspaola10) August 29, 2017
Four patients were being examined by firefighter-paramedics, the Los Angeles County Fire Department said.
Rios captured video of the bus engulfed in fire and published the footage on Twitter.
The cause of the blaze was unknown.