Los Angeles court records show that a judge granted the couple a divorce May 13, about eight months after Moss moved to end her marriage to the "Saturday Night Live" star.
The two got married in October 2009 but separated in June 2010. They do not have any children.
No details of any financial settlement were filed with the court.
Moss portrays career-oriented Peggy Olson on AMC's Emmy Award-winning "Mad Men." Armisen has appeared on NBC's "Saturday Night Live" since 2002 and parodies President Barack Obama on the show.
The Associated Press contributed to this report.