Authorities said they found between 20 to 25 pounds of meth amphetamine along with some weapons.
Apparently, the house had been under surveillance for some time, but the bust came after agents spotted one of the suspects destroying alleged evidence.
The raid was carried out by an interagency task force, including members of the California Bureau of Narcotics Enforcement.
That unit is facing major layoffs because of the state's budget crisis. It could be losing a third of its agents by the end of the year.