Wired Magazine reported that the spyware has resisted efforts to remove it from the computers at a base in Nevada, where pilots remotely fly Predator and Reaper drones in places like Iraq and Afghanistan.
There were no confirmed reports that classified data was lost and it's uncertain if the virus was part of a directed attack or accidentally infected the networks.
The Air Force said in a statement it doesn't discuss threats to its computer networks because it can help hackers refine their tactics.
The Associated Press contributed to this report.
