The crash occurred at Foxen Canyon Road and Orcutt Garey Road.
Officials say the bus collided with a truck and rolled off the road into some trees. First responders say one person was seriously hurt, but most of the other injuries were minor.
A total of four people were transported to an area hospital.
The bus driver was temporarily pinned in the bus.
The cause of the accident is under investigation by California Highway Patrol.
ABC News contributed to this report.