A vandal apparently tossed white paint onto the mural, which is located on an exterior wall outside the venue in the 8000 block of Sunset Boulevard.
Asked to describe what she thought the vandalism represented, activist Shannon Morton replied: "Hatred -- and I think the world is so full of hatred. And it makes me very sad, because this place -- especially on this corner, and what the Laugh Factory and Black Women Lead have tried to do is cultivate a space of love and unity. And when I see blatant hatred like this, it makes me sad for our community."
Laugh Factory officials said it was at least the fifth time vandals have tried to destroy the mural, with the most recent incident being the worst.
"It makes me sad," said Enrique Salazar, a spokesperson for the comedy club. "There's so much hatred still in the world. And this wasn't disrupting anybody, this wasn't causing any violence or issue, it was just making -- bringing awareness. And especially right in front of a place that brings happiness and laughter and joy, and our mission is just to bring joy and unity through laughter."
LAPD officer who shared Valentine-themed George Floyd meme cleared of wrongdoing
The mural, which was unveiled last year, depicts Floyd's face along with the names of other people who have been killed by police.
"When I look at this vandalism, I see people who actually want to burn the world down," said comedian Tehran Von Ghasri. "It's a reminder that hate is real and it's a reminder that racism is very real. It's a reminder that there are people that walk amongst us, that look like us but do things like this."
The LAPD is investigating the incident. No description of a suspect has been released.