Marie died Thursday at 2 p.m. in Van Nuys, according to her official website. She had been resting in bed when a caretaker found she had stopped breathing, said family spokesman Harlan Boll.
She played Sally Rogers on the celebrated 1960s sitcom "The Dick Van Dyke Show."
Marie was a comedy writer at the time on the show and said years later, women would come up to her and say, "Thank you for showing me the way. I wouldn't have become a writer if it wasn't for you."
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In the 70s, she would go on and become one of the stars of the "Hollywood Squares." She also starred on "The Doris Day Show."
She appeared in numerous movies as a child and starred in the Broadway musical "Top Banana." She was nominated for three Emmys and received a star on Hollywood's Walk of Fame in 2001.
Her career in entertainment started when she was just 3 years old and lasted until she passed. The subject of the 2017 documentary "Wait for Your Laugh," Marie often claimed she had the longest career in entertainment history.
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As she aged, "Baby Rose Marie" became "Miss Rose Marie" and then just Rose Marie. She insisted on that with her first agent.
"He said, 'It should be Rose Marie guy,' I said, 'No, no, I'm all grown up. Take the 'miss' off, take the 'baby' off. It's now Rose Marie!" she recalled. "I was the first one with one name -- remember that!"
ABC7's George Pennacchio interviewed Marie at her home just last month for the documentary. It would turn out to be her last on-camera interview.
Rose Marie's signature look became the bows she wore in her hair. Her late husband, trumpet player Bobby Guy, loved that she always wore colorful bows.
"And when he passed away, I said, 'I got to do something to remember him by, it means too much to me,' and I started wearing the black bow," she recalled again. "So every time I wear the bow, I think of him. I think of him laughing at me. He thought I was very funny."
Marie saved memories of her entire career in rooms, on walls, in places all over her house.
"I'm very happy with the life I've had," Marie said in her last interview. "I'm only sorry I wish I could live it over again. It was wonderful. It was wonderful. The whole thing was wonderful."
The Associated Press contributed to this report.