The recreational vehicle smashed into at least six other cars during the chase, shredding the side of the vehicle's passenger side open.
In the middle of the chase, one of the dogs jumped out through the smashed front windshield and ran off as she continued driving.
It finally ended when the RV collided into a car in Tarzana and the woman jumped out and fled on foot. Officers quickly tackled her and took her into custody as she was trying to jump the fence of a home in the neighborhood.
The wild ending to the chase stunned neighbors of the quiet neighborhood.
"These streets are narrow," said Tarzana resident Craig Friedman. "Sure, she was just evading police, but my God, you gotta stop. You know you're gonna get caught."
The chase started around 7 p.m. in the Santa Clarita area for failure to yield, according to the California Highway Patrol.
AIR7 HD was over the pursuit as the suspect struck a palm tree in a shopping center before continuing. The front end and passenger's side of the RV had significant damage, with the windshield smashed in and the door missing.
At several points, the woman was driving up to 60 mph on surface streets. The driver also smashed into several vehicles, including a sedan in an intersection.
The man who was in that vehicle suffered six broken ribs and a punctured lung and was being treated at a local hospital.
Authorities were able to recover the first dog that jumped out of the vehicle. An animal control officer was able to loop the second dog, which appeared to be injured, at the scene. It was leaving bloody paw prints behind as it stayed by the woman's side.
The dog was being checked by a veterinarian.
The driver crashed into a white Hyundai sedan in Tarzana and fled on foot with the second dog for a short time before being taken into custody around 7:30 p.m. near Tampa Avenue and Wells Street.
Two people inside the Hyundai were injured.
The suspect, described as a woman in her 40s, also suffered unknown injuries and was treated by first responders at the scene.
She is expected to face charges that include driving under the influence, felony evading and felony hit-and-run.