The parade began at 11 a.m. at Crescent Heights Boulevard and continued west along Santa Monica Boulevard to Robertson Boulevard.
A traditional moment of silence was held at noon "to remember those who are no longer with us, or cannot be here today, to celebrate those who fought for pride and the freedoms we now enjoy and to think of those who cannot celebrate pride and remain oppressed," organizers said.
The event is one of the hallmarks of Pride weekend. Rev. Troy Perry and 13-year-old transgender activist Zoey served as the grand marshals of this year's parade.
Channing Tatum and Matt Bomer danced in the parade, promoting their new movie "Magic Mike XXL."
L.A. Mayor Eric Garcetti was also in the parade and showed his pride for the city.
The parade has been held yearly since 1970, except in 1973 when infighting over previous year displays left organizers in disarray. The parade was held in Hollywood until 1979, when it was moved to West Hollywood.
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Parade road closures effective until 5 p.m.:
For more information on this event, visit http://lapride.org.
City News Service contributed to this report.