Rescuers had to cut the woman out of the car. She was taken to a nearby trauma center in critical condition.
Considering the impact by the big rig, officials say the woman is lucky she wasn't more seriously injured.
Authorities said the truck, without a trailer, struck the victim's car, causing it to bounce off a telephone pole.
Anyone with any information about the hit-and-run is asked to contact the Los Angeles Sheriff's department at (562) 949-2421.
City News Service contributed to this story.
