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The FBI and the San Bernardino Sheriff's Department also announced reward amounts being offered in connection with the case.
The FBI is offering a reward of $25,000 in exchange for information leading to the recovery of Briant Rodriguez. San Bernardino County is also offering $25,000.
According to the San Bernardino County Sheriff's Department, the men invaded the home and tied up the mother Maria Rosalina Milan and her five children, ransacked the house, and fled with the youngest child, 3-year-old Briant Rodriguez on Sunday. Authorities say the men stole money and other property.
The father was at work and not at home at the time.
Investigators say the Spanish-speaking kidnappers may be from Mexico. Border agents were notified and the FBI is involved in the investigation.
An Amber Alert was issued for Briant Rodriguez, who is a Hispanic boy, about 3 feet tall, 40 pounds and was last seen wearing a yellow shirt with blue sleeves, blue striped shorts and black sandals. He has long brown hair and brown eyes.
One suspect is described as a light-skinned Hispanic male adult, about 18 years old, skinny build, about 5 feet, 8 inches tall, and was wearing a black ball cap, blue jeans and a green T-shirt.
The second suspect is described as a light-skinned Hispanic male adult, about 24 years old, skinny build, about 5 feet, 10 inches tall, and was wearing a black shirt, black pants, black boots and a white bandana.
Anyone with information is urged to call San Bernardino County Sheriff's deputies at (866) 346-7632.