"In the 59-year history of the Golden Globes as of tonight, one other sci-fi film has gotten the award. One. E.T.," said Cameron.
On the acting front, Jeff Bridges won best actor in a drama for "Crazy Heart."
Robert Downey Jr., won in the comedy category for "Sherlock Holmes."
Meryl Streep and Sandra Bullock shared the best actress prize at Friday's Critics Choice Movie Awards.
At the globes, they each won again. Streep, her sixth golden globe, won this time for comedy for "Julie and Julia."
Bullock won her first award for drama in "The Blind Side,"
"I'm as shocked as I think many people are that I've been this lucky and this blessed. I don't expect coming to win anything, and I don't know what to make of it," said Bullock.
"The award itself is from the Hollywood Foreign Press, who have seen me for 30 years in movies, and they're still not sick of me. That means something to me, it really does, because it's hard to remain new," said Streep.
Christoph Waltz won best supporting actor for his role in "Inglourious Basterds," and Mo'nique took home supporting actress for "Precious." She reflected on what her accomplishments can tell other women.
"Dream the impossible dream, and don't believe the sky is the limit. Go above it," she said.
And while the spotlight was on who took home golden trophies, many people's thoughts were not far from the crisis in Haiti.
Nominee George Clooney is helping to organize a telethon that will take place next Friday.
"There are few times in our lives that you see this kind of tragedy, and everybody even at a time where there's great difficulty in our own country, in our own economy, there is great compassion for people of Haiti," said Clooney.