The one of the many questions fans want answered is the fate of Kate Austen and James "Sawyer" Ford. Will the two get back together?
"You'll have to wait and see, we don't know yet," said Evangeline Lilly, who plays Kate Austen.
"We don't know yet. That is something that is kind of touchy, because in order to keep the integrity of a character, he did love Juliet, it can't be that he is just suddenly, 'Oh, she's gone lets get it,' you know," said actor Josh Holloway, who plays "Sawyer." "People would hate him and he would be dead tomorrow. So I don't really know about all of the fireworks and if it does happen it will be later."
"Lost" (Season 1, Episode 1) began with a plane falling apart in mid-air, but during this season premiere there's a scene where the same plane apparently doesn't crash.
Last season, we saw actress Elizabeth Mitchell disappear into a deep hole. Now finally on Tuesday night fans will be able to see what she does at the bottom of it.
There's also a scene with Locke, played by Terry O'Quinn, who looks seemingly alive and seemingly dead. So what is it?
"I'm 11 episodes ahead of you, that is how far I am," said O'Quinn. "But at the end of last season, when Locke was rolled out of that box, I as a viewer and an actor, said 'Apparently this person I was playing is dead.' So now I'm someone else. And early in Season 6 it is revealed who that someone else is."
And we can't ignore the show's evil-doer Benjamin Linus, played by Michael Emerson. I asked Emerson if he thinks Ben deserves to die at the end of the season.
"A sense of deserving? No, Ben deserves happiness like every other person does," said Emerson.
The show's producers say when "Lost" ends in May, it's definitely over -- there won't be any spinoffs or sequels.
"Lost" kicks off with a 2-hour season premiere on Tuesday, Feb. 2, on ABC7.