Everyone screamed when Winfrey made the announcement and actor John Travolta joined her on stage. The two danced hand-in-hand to "Love Train" by the O'Jays.
The show included a few surprise visitors, including actor Don Johnson and singer Paul Simon, who sang a song he wrote for the talk show host.
There are only 130 episodes left this season of "The Oprah Winfrey Show," before it's all over. But for cable viewers, there's more Winfrey to come. She's set to launch her Oprah Winfrey Network, or OWN, on cable Jan. 1.
The Associated Press contributed to this report.
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