The crash occurred around 4:45 a.m. near the Crenshaw Boulevard exit near Jefferson Park.
One female motorist died at the scene and two others suffered minor injuries. Officials also said a vehicle fire broke out.
All westbound lanes were shut down and traffic was snarled for at least two miles, said CHP. Drivers were encouraged to take side streets like Washington and Adams boulevards.
Lanes re-opened around 9:29 a.m. The crash was under investigation.
The Associated Press contributed to this report.