Snow ranging from several inches to more than a foot blanketed states from Louisiana to the Carolinas. Freezing rain in some areas added to the misery and schools around the region remained closed for a second day.
The storm also shut down most cities and towns and closed many businesses. Most flights at Atlanta's Hartsfield-Jackson International Airport, the world's busiest, were canceled. At least nine people were killed in weather-related traffic accidents.
Most of North Carolina remained under a winter storm warning.
The system that's moving northeast has actually merged with a Midwest snow maker.
Snow and ice are making roads treacherous and more than 1,000 flights have already been canceled.
Meanwhile, New York could end up with an additional 7 to 14 inches of snow and more than a foot could be headed to Boston. A Christmas blizzard dumped more than 2 feet of snow on New York City and other parts of the region, crippling holiday travel and nearly shutting down major cities.
The National Weather Service issued a winter storm warning from Tuesday evening through Wednesday afternoon, with the heaviest snowfall expected overnight.
The Associated Press contributed to this report.