School faculty member Dr. Jonathan Fielding and his wife presented the gift, and in return, the school will be renamed the UCLA Jonathan and Karen Fielding School of Public Health.
UCLA Chancellor Gene Block said he was humbled by the generosity of the Fieldings' gift.
"This investment from longtime champions of public health reflects our shared confidence in the UCLA School of Public Health as a resource not only for greater Los Angeles but the entire world and will extend the school's reach as a global leader in teaching and service," said Block.
Jonathan Fielding is a professor of health services and pediatrics and joined the UCLA faculty in 1979. He is also the founding director of the Los Angeles County Department of Public Health Services.
Karen Fielding serves in The Everychild Foundation, a charitable organization that works with children suffering from disease, disability, abuse, neglect or poverty. She is also a court-appointed special advocate and works with children in foster care.
According to a school statement, the donation will be used to support faculty, students and educational infrastructure. The money will also fund a chair in population health, which works to improve health through non-health sectors like transportation, housing and education.