The shooting happened at a GameStop store located at 3183 Wilshire Boulevard just after 1 a.m.
A crowd was gathered outside the GameStop for the midnight release of the highly anticipated game "Call of Duty."
Authorities say the shooter walked up to the man, shot him several times in the abdomen, and then took off.
The victim, who was in a wheelchair, is in stable condition.
The circumstances of the shooting were under investigation. Anyone with information was urged to call LAPD at (213) 473-0476.