The victims, said to be a man and woman in their 60s, were in grave condition after they were pulled from the burning home located in the 3100 block of Malabar Street.
There was no word on the cause of the fire, which started just after 9 a.m. Fire officials say the home had no smoke alarms.
Two firefighters were treated for smoke inhalation. The blaze was doused in about 20 minutes.
City News Service contributed to this report.