Onramps and transition roads to the southbound 405 will begin closing at 7 p.m. Monday.
All southbound traffic from the 101 Freeway to Getty Center Drive will begin to shut down at 10 p.m. Southbound lanes will be completely blocked at the 101 at midnight.
Southbound 405 lanes are scheduled to re-open at 5 a.m. Tuesday.
Caltrans crews will continue work on the Mulholland Drive bridge overnight Monday.
