She has been plastered all over international headlines as a murderer and seductress.
Or is she what so many in the U.S. believe, an innocent American victimized by a flawed Italian justice system?
The elusive Knox has now put herself in the spotlight with a new book, "Waiting to be Heard."
Knox sat down with ABC News' Diane Sawyer in her first television interview, revealing how difficult it was to be jailed for four years for a murder she says she did not commit.
Asked if she ever thought about suicide while incarcerated, Knox said, "I did. There are plenty of ways that you could kill yourself and people did, and I imagined doing them all."
In 2007, Knox arrived in Italy as an American college student studying overseas. When her roommate, Meredith Kercher, was murdered, Knox quickly became one of the prime suspects and the center of a tabloid storm.
Sawyer said she got to know a great deal about the mysterious woman.
"Nothing was off limits and we did spend a long time with her," Sawyer said. "I think you're going to see a young woman of many moods, at times guarded, at times open, at times laughing, at times in tears. Most of all, she said she wants to be reconsidered as a person after all those tabloid lurid headlines."
Knox is still a murder suspect. She awaits a new trial.
Sawyer examines the evidence.
"You will also be fascinated, though, when we get into the courtroom and take a very close look at the evidence presented by the prosecution, and you'll get to judge for yourself whether you think this was guilty beyond a reasonable doubt or not," Sawyer said.
