Police responded to the Westfield Mission Valley Mall outside a Macy's department store shortly after 1 a.m. Officers say a woman called 911 and stated that she was shot.
Officers arrived and found the shooting victims. A female victim was declared dead at the scene. Her name has not been released. A male victim was rushed to Scripps Mercy Hospital in unknown condition. Police say both victims were shot in the head and upper body.
A motive for the shooting is unknown at this time. The suspect's vehicle was described as a 2008 to 2011 gray Honda.
Authorities say Macy's was open at the time, and investigators are looking for witnesses. Anyone with information is urged to call the San Diego Police Department's Homicide Unit at (619) 531-2293 or San Diego County Crime Stoppers at (888) 580-8477.
City News Service contributed to this report.