According to the Federal Aviation Administration, the single-engine Cessna 172 crashed at about 6:30 p.m. Thursday, approximately 800 feet west of a runway at Fresno's Chandler Airport.
The plane hit a tree before crashing and caught fire on impact. No one on the ground was injured.
Authorities said the two victims were the pilot and the boy. Their names were not released.
The Fresno Police and Fire Departments were on the scene Thursday evening. The FAA and NTSB will also investigate.
The Associated Press contributed to this report.