Los Angeles firefighters responded to the 10350 block of North San Fernando Road around 1 p.m. following reports of a small plane down.
Ian Gregor, a spokesman for the Federal Aviation Administration, says a single-engine Cessna 172 was inbound to Whiteman Airport when the pilot decided to execute a missed approach and come around for another landing attempt.
During the landing approach, Gregor says, the plane struck a building and crashed into a used car lot.
Officials say two male adults in their 30s had self-extricated themselves from the aircraft. Both were transported to a local hospital via ambulance with non-life threatening injuries.
No fire was reported.
San Fernando Road was closed to all traffic between Pierce and Osborne streets following the incident.
The investigation is being handled by the FAA and the NTSB.
Investigators will be looking into whether weather conditions played a part in the crash. The National Weather Service hoisted Red Flag Warnings for much of Los Angeles Sunday.
Whiteman Airport is a small general aviation facility at the eastern end of the San Fernando Valley, about halfway between Burbank and San Fernando.
The plane knocked down three electrical poles, taking out power in the area. An estimated 2,000 to 3,000 customers were without power. One of the poles has been fixed, but utility crews are working to restore all service by Sunday night.