The violent collision occurred about 12:30 a.m. near Grove Avenue and forced the closure of all eastbound lanes, according to the California Highway Patrol. Several lanes were later reopened, but traffic was backed up for miles as the morning commute got underway hours later. Motorists were urged to use Philadelphia Street as an alternative route.
The identity of the deceased victim was not immediately disclosed.
The cause of the crash is under investigation by the CHP.