Lopez's wife made headlines when she donated her kidney to the ailing comedian.
In a statement released to Eyewitness News, the couple said through a publicist:
"George and Ann Lopez have made the decision to end their 17-year marriage. The decision is amicable and by mutual agreement. They remain dedicated parents, and committed partners in business and their philanthropic organization, /*The Lopez Foundation*/."
The Associated Press contributed to this report.
