Rev. Jeff Carr has served as chief of staff for the past two years. Before that he was the city's gang czar.
"For the last two years, Reverend Jeff Carr has served as my chief of staff, honorably leading this administration and moving our agenda forward," said Villaraigosa in a statement. "I look forward to working closely with him through this transition and in the years ahead."
The Mayor's Office issued a statement saying Carr intends to return to the non-profit sector.