The incident happened at the intersection of 6th and Mateo streets around 7:50 p.m.
Authorities said the man was crossing the street mid-block when he was hit by a driver heading southbound on Mateo Street.
The man, whose identity was not released, was transported County USC Hospital where he was pronounced dead.
The suspect's vehicle was described as a light-colored SUV.
Anyone with information regarding the hit-and-run was urged to call Los Angeles police at (877) 527-3247.
