Firefighters were dispatched at about 7:30 p.m. to Inner Gardens, a nursery and garden fixture design firm, in the 6050 block of West Jefferson Boulevard.
PHOTOS: Commercial building on fire near Culver City
Fire officials reported the flames had burned through the roof and the structure began to collapse within the 12 minutes of the first 911 call. The fire was put out in about 68 minutes.
Damages were mostly confined to Inner Gardens, but a neighboring art framing store received some smoke and water damage.
No injuries were reported.