Officials said the calls were regarding players getting access to fire stations where Pokemon characters have been spotted.
MORE: 'Pokemon Go' players attacked by armed robber in Lakewood park
"Individuals that are playing the game are showing up to stations, knocking on the door, trying to gain access because they're characters inside the station that they're trying to get," Richard Licon with the Los Angeles County Fire Department said.
*ATTENTION* Please do not dial 911 or impact fire stations regarding POKEMON GO. 911 is for EMERGENCIES ONLY.— LACounty Fire PIO (@LACoFDPIO) July 14, 2016
While firefighters were out responding to emergencies, players were calling 911 asking if the firefighters could come back to the fire station, according to officials.
"Actually tie up our dispatch trying to answer their questions in regards to the 'Pokemon Go' game instead of handling some of the EMS calls coming in," Licon said.
MORE: 'Pokemon Go' explained for those who do not 'Pokemon Go'
"Pokemon Go" is a free mobile game app that allows players roam around the real world to capture fictional Pokemon creatures.
Within the first five days, the app was downloaded more than 7.5 million times, according to data from market intelligence firm Sensor Tower.