Broward County sheriff's officials said the suspect was not harmed and was taken into custody without incident. He was being interviewed by sheriff's detectives and FBI investigators.
Fort Lauderdale Mayor Jack Seiler said there was only one shooter behind the attack.
Officials said Santiago was arrested after he apparently ran out of ammunition at the airport. He was lying down at the terminal when he was taken into custody.
THE IMPACT:
Federal official tells ABC News that all departures and arrivals at the airport are currently suspended until the situation is resolved.
LAX Airport Police said security has been increased in terminals and baggage areas in response to the Ft. Lauderdale shooting.
Bob Hope Airport in Burbank also said security measures were increased as a precaution.
Authorities said there are no threats to Southern California airports following the deadly rampage in Florida.
There are six arriving and six departing nonstop flights between LAX and FLL scheduled for Friday. Passengers are advised to check with their airlines regarding flight status.
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A law enforcement officer evacuates a civilian from an area at Fort Lauderdale-Hollywood International Airport, Friday, Jan. 6, 2017, in Fort Lauderdale, Fla.