The victim, Edras Velasquez, was a passenger on a moped-type scooter.
He had been in a coma since the crash last week, but he died Monday night.
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The wreck happened at the intersection of Glendale Boulevard and Waverly Drive.
A GoFundMe page has been set up for the Velasquez family.
LAPD announced the $50,000 reward, which is being offered for information that leads to an arrest and conviction in this incident, which was changed from a felony hit-and-run traffic crash to a vehicular manslaughter case.
If you have any information about this case, you're urged to contact police.