For the second time this month, the westbound lanes between Lake Avenue and Mountain Street were shut down, along with the eastbound ramp from the 134 Freeway to the westbound 210.
Along the 210 Freeway, the Marengo Avenue and Mountain Street offramps will also be closed as well as the Walnut Street onramp.
The closures were expected to reopen by 5 a.m. on Monday.
The closures are part of a $148.5 million pavement rehabilitation project for both directions of the freeway in the cities of Glendale, La Canada Flintridge and Pasadena. Caltrans said the repaved freeway will provide a smoother surface for drivers.
The road project was set to be completed in 2018.