Emergency crews got to the scene and found two cars flipped over. Two people were ejected from a van that was involved in the accident, authorities said. Both of those people died. Officers said there were eight people riding in the van. Three other passengers in the vehicle were taken to the hospital in critical condition.
The female driver of the other car involved was also airlifted to the hospital as a precaution.
"They lane changed into each other. We don't know which one. The reactions of the drivers caused them to strike the center divider and overturn," California Highway Patrol Sergent Al Aleman.
All lanes of the northbound 605 Freeway near the intersection of the 91 Freeway were closed until about 11 p.m. Wednesday.
An investigation has been launched to discover the cause of the crash.