Gibson's home jersey from Game 1 of the World Series went for $303,277.20.
His batting helmet sold for $153,388.80.
Proceeds from part of the sale will benefit the Kirk Gibson Foundation.
The identities of the winning bidders weren't revealed.
Also, a 1934 Babe Ruth professional-model bat used by Ruth to hit career home run No. 702 sold for $137,865.60, a Ty Cobb H&B side-written professional model game-used bat went for $75,330, and a 1953 Mickey Mantle New York Yankees game-worn, autographed road jersey sold for $62,256.
The Associated Press contributed to this report.