It took in $26.3 million this weekend.
The Coen brothers' "True Grit" starring Jeff Bridges came in second with $24.5 million.
"TRON: Legacy," also starring Bridges, ranked third, taking in $18.3 million.
"Yogi Bear" came in fourth with $13 million, While "The Chronicles of Narnia: The Voyage of the Dawn Treader" rounded out the top five with $10.5 million.
1. "Little Fockers," $26.3 million.
2. "True Grit," $24.5 million.
3. "Tron: Legacy," $18.3 million.
4. "Yogi Bear," $13 million.
5. "The Chronicles of Narnia: The Voyage of the Dawn Treader," $10.5 million.
6. "Tangled," $10.01 million.
7. "The Fighter," $10 million.
8. "Gulliver's Travels," $9.1 million.
9. "Black Swan," $8.5 million.
10. "The King's Speech," $7.6 million.
The Associated Press contributed to this report.