Experts say Lady Gaga's wild, no-holds-barred wardrobe has created a fashion revolution.
CFDA president Diane von Furstenberg and executive director Steven Kolb announced the nominees and honorees for the annual industry awards at a reception Wednesday evening at the DVF studio.
The other major prize to be awarded by the CFDA will go to Marc Jacobs, considered by insiders to be the most influential American designer working now.
Jacobs was also nominated in the competitive womenswear designer of the year category against Alexander Wang, and the design duo Lazaro Hernandez and Jack McCollough of Proenza Schouler.
Also nominated in the womenswear category for emerging talent are twins Ashley and Mary-Kate Olssen for their collection, The Row.
The ceremony takes place June 6 at New York City's Lincoln Center.
The Associated Press contributed to this report.