Taylor Swift, Aerosmith, Rihanna, Usher, Bon Jovi, Lil Wayne, Green Day, Miranda Lambert, Mary J. Blige and Shakira are among the artists set to take the stage at the MGM Grand on Sept. 21 and 22.
Clear Channel, which also owns 850 terrestrial radio stations in the U.S., said the lineup also includes Brad Paisley, Pitbull, Enrique Iglesias, No Doubt, Linkin Park, Jason Aldean, P!nk, deadmau5, Swedish House Mafia and Calvin Harris.
Last year's debut of the festival featured artists such as Jay-Z and Lady Gaga.
Tickets go on sale July 14. The concert will play live on iHeartRadio.com and Clear Channel stations nationwide.
Get more information about the festival: www.iHeartRadio.com/vegas
The Associated Press contributed to this report.