Police received a domestic violence call from a home in the 3100 block of Almeria Street at about 10:30 p.m. Friday.
When officers arrived, they found 45-year-old Michelle Stamper fatally shot and 55-year-old Johnny O'Kane suffering from a gunshot wound. O'Kane was transported to a local hospital in critical condition.
The incident appeared to be an attempted murder suicide.
The investigation is ongoing.
Anyone with information regarding this incident is urged to contact Harbor Area Homicide Detective David Alvarez at (310) 726-7879.