The incident occurred at the Studio 6 hotel located on the 13500 block of Sherman Way.
Officers from the LAPD North Hollywood Station Narcotics Division were executing a search warrant around 10:30 p.m. when they found an item, which resembled a pipe bomb, in the suspects' room.
The hotel was then evacuated for a bomb threat investigation. A bomb squad blew up the pipe and rendered it safe around 12:30 a.m. Tuesday
Three people from the original narcotics search warrant were arrested.