The lasers are dangerous because when they hit the windshield, they fill the cockpit with light, disorienting pilots or causing temporary blindness. Some pilots have sustained long-term visual impairment.
Authorities said Sunday that two of the suspects are a 15-year-old boy from Pico Rivera and a 16-year-old boy from Los Alamitos.
They face charges in incidents in the Pico Rivera sheriff's station area in December and April.
The other two are 25-year-old men from La Puente and Maywood for incidents in September and December.